BRD-K87909389_alvocidib_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K87909389_alvocidib_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
C10ORF2 chromosome 10 open reading frame 2
C8ORF33 chromosome 8 open reading frame 33
CALB1 calbindin 1, 28kDa
CALD1 caldesmon 1
CCDC6 coiled-coil domain containing 6
CCDC93 coiled-coil domain containing 93
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CFD complement factor D (adipsin)
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLDN3 claudin 3
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSC2 desmocollin 2
EFNA1 ephrin-A1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F12 coagulation factor XII (Hageman factor)
FAM63A family with sequence similarity 63, member A
FBP1 fructose-1,6-bisphosphatase 1
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GGT1 gamma-glutamyltransferase 1
GLS glutaminase
GMFB glia maturation factor, beta
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
JAG1 jagged 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K3 mitogen-activated protein kinase kinase 3
NDRG1 N-myc downstream regulated 1
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHF20 PHD finger protein 20
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLIN2 perilipin 2
PPARD peroxisome proliferator-activated receptor delta
PRR7 proline rich 7 (synaptic)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAE1 ribonucleic acid export 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAP1GAP2 RAP1 GTPase activating protein 2
RARA retinoic acid receptor, alpha
RBP1 retinol binding protein 1, cellular
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
SATB2 SATB homeobox 2
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SGSH N-sulfoglucosamine sulfohydrolase
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD7 SMAD family member 7
SNN stannin
SPEN spen family transcriptional repressor
SRSF11 serine/arginine-rich splicing factor 11
SST somatostatin
STMN2 stathmin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAGLN transgelin
TICAM1 toll-like receptor adaptor molecule 1
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WT1 Wilms tumor 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
AKAP7 A kinase (PRKA) anchor protein 7
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLMH bleomycin hydrolase
C4ORF27 chromosome 4 open reading frame 27
CAST calpastatin
CBR3 carbonyl reductase 3
CBX1 chromobox homolog 1
CDCA3 cell division cycle associated 3
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHD9 chromodomain helicase DNA binding protein 9
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP11 FK506 binding protein 11, 19 kDa
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
HOXB2 homeobox B2
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
ITGB4 integrin, beta 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LOXL2 lysyl oxidase-like 2
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MANSC1 MANSC domain containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MPDU1 mannose-P-dolichol utilization defect 1
MSMB microseminoprotein, beta-
MYH10 myosin, heavy chain 10, non-muscle
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL8 oxysterol binding protein-like 8
PAIP1 poly(A) binding protein interacting protein 1
PCM1 pericentriolar material 1
PLK1 polo-like kinase 1
PLS1 plastin 1
PLSCR1 phospholipid scramblase 1
POU2AF1 POU class 2 associating factor 1
PRKD3 protein kinase D3
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PURA purine-rich element binding protein A
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RDX radixin
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCF4 transcription factor 4
TESC tescalcin
THBS2 thrombospondin 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM29 tripartite motif containing 29
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
WIPF1 WAS/WASL interacting protein family, member 1
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB38 zinc finger and BTB domain containing 38