BRD-K87909389_alvocidib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K87909389_alvocidib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARHGAP25 Rho GTPase activating protein 25
ASPH aspartate beta-hydroxylase
ASPN asporin
BBX bobby sox homolog (Drosophila)
BLNK B-cell linker
BPIFA1 BPI fold containing family A, member 1
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALR calreticulin
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCRL2 chemokine (C-C motif) receptor-like 2
CD302 CD302 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD84 CD84 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHODL chondrolectin
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC10A C-type lectin domain family 10, member A
CLEC7A C-type lectin domain family 7, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTSK cathepsin K
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCN decorin
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FLT1 fms-related tyrosine kinase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOXF2 forkhead box F2
FPR3 formyl peptide receptor 3
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC4 glypican 4
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSN gelsolin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTRA1 HtrA serine peptidase 1
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGSF6 immunoglobulin superfamily, member 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LOC100272216 uncharacterized LOC100272216
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB1 nucleobindin 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH17 protocadherin 17
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZD2 PDZ domain containing 2
PEG3 paternally expressed 3
PLD3 phospholipase D family, member 3
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SSPN sarcospan
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCTN1 tectonic family member 1
TF transferrin
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM140 transmembrane protein 140
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM231 transmembrane protein 231
TMEM47 transmembrane protein 47
TOX thymocyte selection-associated high mobility group box
TREM2 triggering receptor expressed on myeloid cells 2
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
WFDC2 WAP four-disulfide core domain 2
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
AHNAK AHNAK nucleoprotein
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF4E eukaryotic translation initiation factor 4E
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GLOD4 glyoxalase domain containing 4
GRSF1 G-rich RNA sequence binding factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
JMJD6 jumonji domain containing 6
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MRPS2 mitochondrial ribosomal protein S2
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PPIF peptidylprolyl isomerase F
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RPL36AL ribosomal protein L36a-like
SACS sacsin molecular chaperone
SCAND1 SCAN domain containing 1
SERBP1 SERPINE1 mRNA binding protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRSF3 serine/arginine-rich splicing factor 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
U2AF1 U2 small nuclear RNA auxiliary factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WEE1 WEE1 G2 checkpoint kinase