BRD-K87909389_alvocidib_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

283 genes differentially expressed following the BRD-K87909389_alvocidib_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACKR3 atypical chemokine receptor 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARL4C ADP-ribosylation factor-like 4C
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
CA11 carbonic anhydrase XI
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC6 coiled-coil domain containing 6
CCDC68 coiled-coil domain containing 68
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CDCP1 CUB domain containing protein 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHEK1 checkpoint kinase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
COG2 component of oligomeric golgi complex 2
CSNK1D casein kinase 1, delta
CTSZ cathepsin Z
DACH1 dachshund family transcription factor 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP6 dual specificity phosphatase 6
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FJX1 four jointed box 1 (Drosophila)
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
HEBP1 heme binding protein 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IST1 increased sodium tolerance 1 homolog (yeast)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LAPTM5 lysosomal protein transmembrane 5
LASP1 LIM and SH3 protein 1
LYPD1 LY6/PLAUR domain containing 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MBD1 methyl-CpG binding domain protein 1
MICB MHC class I polypeptide-related sequence B
MMD monocyte to macrophage differentiation-associated
MMP13 matrix metallopeptidase 13
MREG melanoregulin
MRPS30 mitochondrial ribosomal protein S30
MSLN mesothelin
MXRA5 matrix-remodelling associated 5
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
PCGF2 polycomb group ring finger 2
PEG3 paternally expressed 3
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAE1 ribonucleic acid export 1
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SOD2 superoxide dismutase 2, mitochondrial
TERF2 telomeric repeat binding factor 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TPGS2 tubulin polyglutamylase complex subunit 2
UBE3B ubiquitin protein ligase E3B
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WDR3 WD repeat domain 3
ZNF23 zinc finger protein 23
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CALML3 calmodulin-like 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
CH25H cholesterol 25-hydroxylase
CKAP4 cytoskeleton-associated protein 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNN1 calponin 1, basic, smooth muscle
COL14A1 collagen, type XIV, alpha 1
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DLC1 DLC1 Rho GTPase activating protein
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
EGF epidermal growth factor
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EVL Enah/Vasp-like
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FGF13 fibroblast growth factor 13
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
H2AFV H2A histone family, member V
HAPLN1 hyaluronan and proteoglycan link protein 1
HAS2 hyaluronan synthase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HOMER2 homer scaffolding protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGSF3 immunoglobulin superfamily, member 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
INTS3 integrator complex subunit 3
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KNG1 kininogen 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMCD1 LIM and cysteine-rich domains 1
LOXL1 lysyl oxidase-like 1
LUM lumican
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICALL1 MICAL-like 1
MOK MOK protein kinase
MTSS1 metastasis suppressor 1
MYBPC1 myosin binding protein C, slow type
MYLK myosin light chain kinase
MZB1 marginal zone B and B1 cell-specific protein
NAP1L1 nucleosome assembly protein 1-like 1
NEBL nebulette
NEK7 NIMA-related kinase 7
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOTCH2NL notch 2 N-terminal like
NREP neuronal regeneration related protein
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL8 oxysterol binding protein-like 8
PAIP1 poly(A) binding protein interacting protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PNISR PNN-interacting serine/arginine-rich protein
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROM1 prominin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCAN1 regulator of calcineurin 1
RDX radixin
RHOBTB3 Rho-related BTB domain containing 3
RHOQ ras homolog family member Q
RNF130 ring finger protein 130
RPS11 ribosomal protein S11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SGMS1 sphingomyelin synthase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SKP1 S-phase kinase-associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQLE squalene epoxidase
SRSF3 serine/arginine-rich splicing factor 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TRAC T cell receptor alpha constant
TRIM29 tripartite motif containing 29
TTC39A tetratricopeptide repeat domain 39A
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBB ubiquitin B
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBL3 ubiquitin-like 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1