BRD-K87909389_alvocidib_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K87909389_alvocidib_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADGRL2 adhesion G protein-coupled receptor L2
AKAP9 A kinase (PRKA) anchor protein 9
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASPN asporin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLNK B-cell linker
BSG basigin (Ok blood group)
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CKAP4 cytoskeleton-associated protein 4
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DMXL2 Dmx-like 2
DNTT DNA nucleotidylexotransferase
DST dystonin
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM3C family with sequence similarity 3, member C
FOLR1 folate receptor 1 (adult)
FRY furry homolog (Drosophila)
GATAD1 GATA zinc finger domain containing 1
GLUL glutamate-ammonia ligase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPNMB glycoprotein (transmembrane) nmb
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HP haptoglobin
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LOC100272216 uncharacterized LOC100272216
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYO6 myosin VI
NEFL neurofilament, light polypeptide
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMYD3 SET and MYND domain containing 3
SRPR signal recognition particle receptor (docking protein)
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP6 syntaxin binding protein 6 (amisyn)
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM259 transmembrane protein 259
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG3 autophagy related 3
ATMIN ATM interactor
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
C1ORF106 chromosome 1 open reading frame 106
CAB39 calcium binding protein 39
CCNA2 cyclin A2
CCNB2 cyclin B2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CLTA clathrin, light chain A
CTBP2 C-terminal binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GPSM2 G-protein signaling modulator 2
GPX2 glutathione peroxidase 2
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KARS lysyl-tRNA synthetase
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LAP3 leucine aminopeptidase 3
LBR lamin B receptor
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NUSAP1 nucleolar and spindle associated protein 1
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROM1 prominin 1
PTTG1 pituitary tumor-transforming 1
PUM1 pumilio RNA-binding family member 1
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNPS1 RNA binding protein S1, serine-rich domain
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SOX9 SRY (sex determining region Y)-box 9
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VGLL1 vestigial-like family member 1
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase