BRD-K87909389_alvocidib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K87909389_alvocidib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAG3 BCL2-associated athanogene 3
C1S complement component 1, s subcomponent
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FOLR1 folate receptor 1 (adult)
GPC4 glypican 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA7 integrin, alpha 7
KDM5D lysine (K)-specific demethylase 5D
KRT6A keratin 6A, type II
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NMB neuromedin B
NME5 NME/NM23 family member 5
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCGF2 polycomb group ring finger 2
PI3 peptidase inhibitor 3, skin-derived
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REG1A regenerating islet-derived 1 alpha
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB2 SATB homeobox 2
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPON1 spondin 1, extracellular matrix protein
STK17A serine/threonine kinase 17a
TSPAN7 tetraspanin 7
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASPN asporin
AURKB aurora kinase B
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CLIC3 chloride intracellular channel 3
COL10A1 collagen, type X, alpha 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DENND1B DENN/MADD domain containing 1B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRAMD1C GRAM domain containing 1C
HIST1H4C histone cluster 1, H4c
HOXC10 homeobox C10
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGSF3 immunoglobulin superfamily, member 3
ISG15 ISG15 ubiquitin-like modifier
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MB myoglobin
MGLL monoglyceride lipase
MX1 MX dynamin-like GTPase 1
MYH10 myosin, heavy chain 10, non-muscle
NNMT nicotinamide N-methyltransferase
OSBPL8 oxysterol binding protein-like 8
PBX3 pre-B-cell leukemia homeobox 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK1 polo-like kinase 1
PRR11 proline rich 11
PTMA prothymosin, alpha
RDX radixin
RGS4 regulator of G-protein signaling 4
RIN2 Ras and Rab interactor 2
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STMN1 stathmin 1
TAGLN2 transgelin 2
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TNNC1 troponin C type 1 (slow)
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
WSB1 WD repeat and SOCS box containing 1
ZEB1 zinc finger E-box binding homeobox 1