BRD-K87909389_HY-10005_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K87909389_HY-10005_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ATP10B ATPase, class V, type 10B
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BLNK B-cell linker
CALD1 caldesmon 1
CCDC176 coiled-coil domain containing 176
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CETN2 centrin, EF-hand protein, 2
CLEC5A C-type lectin domain family 5, member A
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CYBRD1 cytochrome b reductase 1
CYTIP cytohesin 1 interacting protein
DCN decorin
DOK5 docking protein 5
DSE dermatan sulfate epimerase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
FBN1 fibrillin 1
FN1 fibronectin 1
GAS6 growth arrest-specific 6
GLT8D2 glycosyltransferase 8 domain containing 2
GSTA1 glutathione S-transferase alpha 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
IDO1 indoleamine 2,3-dioxygenase 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INA internexin neuronal intermediate filament protein, alpha
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KRT20 keratin 20, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LRRC17 leucine rich repeat containing 17
LXN latexin
MDFIC MyoD family inhibitor domain containing
MUC16 mucin 16, cell surface associated
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POSTN periostin, osteoblast specific factor
PRKCI protein kinase C, iota
PSENEN presenilin enhancer gamma secretase subunit
PYCARD PYD and CARD domain containing
RNASE6 ribonuclease, RNase A family, k6
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TNNC1 troponin C type 1 (slow)
VTCN1 V-set domain containing T cell activation inhibitor 1
XAF1 XIAP associated factor 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
BRD2 bromodomain containing 2
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
CHIC2 cysteine-rich hydrophobic domain 2
CHSY1 chondroitin sulfate synthase 1
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DAAM1 dishevelled associated activator of morphogenesis 1
DBF4 DBF4 zinc finger
DCP1A decapping mRNA 1A
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEFB1 defensin, beta 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EFHD2 EF-hand domain family, member D2
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA11 homeobox A11
HSPA1A heat shock 70kDa protein 1A
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KAT6B K(lysine) acetyltransferase 6B
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KIF14 kinesin family member 14
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDHX pyruvate dehydrogenase complex, component X
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLK2 polo-like kinase 2
PLTP phospholipid transfer protein
PRF1 perforin 1 (pore forming protein)
PROM1 prominin 1
QKI QKI, KH domain containing, RNA binding
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RBM15 RNA binding motif protein 15
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RNMT RNA (guanine-7-) methyltransferase
RPP14 ribonuclease P/MRP 14kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAR1A secretion associated, Ras related GTPase 1A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNRK SNF related kinase
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPATA2 spermatogenesis associated 2
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBP TATA box binding protein
TBX3 T-box 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFB2M transcription factor B2, mitochondrial
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOP1 topoisomerase (DNA) I
TRAF4 TNF receptor-associated factor 4
TRIM32 tripartite motif containing 32
TUFT1 tuftelin 1
TXLNA taxilin alpha
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR43 WD repeat domain 43
WDR82 WD repeat domain 82
WIPF2 WAS/WASL interacting protein family, member 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF131 zinc finger protein 131
ZNF330 zinc finger protein 330
ZNHIT6 zinc finger, HIT-type containing 6