BRD-K86899078_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K86899078_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKAP12 A kinase (PRKA) anchor protein 12
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
COL9A3 collagen, type IX, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00342 long intergenic non-protein coding RNA 342
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1M metallothionein 1M
MYBPC1 myosin binding protein C, slow type
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PADI2 peptidyl arginine deiminase, type II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4B phosphodiesterase 4B, cAMP-specific
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
PRR15L proline rich 15-like
PTN pleiotrophin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TBX3 T-box 3
TCTA T-cell leukemia translocation altered
TNC tenascin C
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
UGP2 UDP-glucose pyrophosphorylase 2
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
GSTA1 glutathione S-transferase alpha 1
IL1R2 interleukin 1 receptor, type II
KLK11 kallikrein-related peptidase 11
KRT17 keratin 17, type I
MYH10 myosin, heavy chain 10, non-muscle
PRKCD protein kinase C, delta
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAT1 signal transducer and activator of transcription 1, 91kDa
TBX2 T-box 2
TNS3 tensin 3
WT1 Wilms tumor 1