BRD-K86899078_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K86899078_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
COL1A1 collagen, type I, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CTGF connective tissue growth factor
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAXDC2 fatty acid hydroxylase domain containing 2
FN1 fibronectin 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
L1CAM L1 cell adhesion molecule
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LPIN1 lipin 1
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
NCAM1 neural cell adhesion molecule 1
NDFIP1 Nedd4 family interacting protein 1
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NUCB2 nucleobindin 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
PRAF2 PRA1 domain family, member 2
PRSS8 protease, serine, 8
PYGL phosphorylase, glycogen, liver
RAB29 RAB29, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
RHOB ras homolog family member B
RHOC ras homolog family member C
RIMS3 regulating synaptic membrane exocytosis 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS related RAS viral (r-ras) oncogene homolog
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
STON1 stonin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VNN1 vanin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFB1 defensin, beta 1
DKC1 dyskeratosis congenita 1, dyskerin
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DSCC1 DNA replication and sister chromatid cohesion 1
DUT deoxyuridine triphosphatase
EED embryonic ectoderm development
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICAM3 intercellular adhesion molecule 3
KIAA0101 KIAA0101
KIF2C kinesin family member 2C
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MRPS16 mitochondrial ribosomal protein S16
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTDSS1 phosphatidylserine synthase 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RELN reelin
RFC3 replication factor C (activator 1) 3, 38kDa
RHCG Rh family, C glycoprotein
RRM1 ribonucleotide reductase M1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SCEL sciellin
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPDL1 spindle apparatus coiled-coil protein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRM spermidine synthase
SRSF10 serine/arginine-rich splicing factor 10
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TIMELESS timeless circadian clock
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
WDR12 WD repeat domain 12
ZWINT ZW10 interacting kinetochore protein