BRD-K86899078_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K86899078_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ADCY7 adenylate cyclase 7
ADGRG1 adhesion G protein-coupled receptor G1
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CCNG2 cyclin G2
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HRASLS HRAS-like suppressor
IDI1 isopentenyl-diphosphate delta isomerase 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
KANK1 KN motif and ankyrin repeat domains 1
KIF14 kinesin family member 14
KRT18 keratin 18, type I
KRT5 keratin 5, type II
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
PAM peptidylglycine alpha-amidating monooxygenase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX10 sorting nexin 10
SPAG4 sperm associated antigen 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
SVIL supervillin
TGFA transforming growth factor, alpha
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AUTS2 autism susceptibility candidate 2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
COL6A1 collagen, type VI, alpha 1
DEFB1 defensin, beta 1
DNM1L dynamin 1-like
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBLN1 fibulin 1
FBXL12 F-box and leucine-rich repeat protein 12
FOXO1 forkhead box O1
GAB2 GRB2-associated binding protein 2
MAGEA3 melanoma antigen family A3
MTUS1 microtubule associated tumor suppressor 1
PAEP progestagen-associated endometrial protein
PBX3 pre-B-cell leukemia homeobox 3
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)