BRD-K86797399_pracinostat_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K86797399_pracinostat_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSS cathepsin S
CXCL11 chemokine (C-X-C motif) ligand 11
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYNLT3 dynein, light chain, Tctex-type 3
ELOVL5 ELOVL fatty acid elongase 5
FLRT3 fibronectin leucine rich transmembrane protein 3
G0S2 G0/G1 switch 2
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS4 lectin, galactoside-binding, soluble, 4
MMD monocyte to macrophage differentiation-associated
MTSS1 metastasis suppressor 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSPH phosphoserine phosphatase
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RPL39L ribosomal protein L39-like
RTN1 reticulon 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SORBS1 sorbin and SH3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AUTS2 autism susceptibility candidate 2
CCL19 chemokine (C-C motif) ligand 19
COL1A2 collagen, type I, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM57A family with sequence similarity 57, member A
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
LTF lactotransferrin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPEPL1 aminopeptidase-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM1 PDZ and LIM domain 1
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PTX3 pentraxin 3, long
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SQSTM1 sequestosome 1
TARP TCR gamma alternate reading frame protein