BRD-K86797399_pracinostat_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K86797399_pracinostat_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL21 chemokine (C-C motif) ligand 21
CFB complement factor B
CHGB chromogranin B
CHRDL1 chordin-like 1
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CTBP2 C-terminal binding protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
FAM46A family with sequence similarity 46, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FGB fibrinogen beta chain
FOXO4 forkhead box O4
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HSPA12A heat shock 70kDa protein 12A
IGFBP6 insulin-like growth factor binding protein 6
LDOC1 leucine zipper, down-regulated in cancer 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN2 perilipin 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYGL phosphorylase, glycogen, liver
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
RTN1 reticulon 1
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
STK26 serine/threonine protein kinase 26
STMN2 stathmin 2
SYT1 synaptotagmin I
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TMEM176B transmembrane protein 176B
TOX3 TOX high mobility group box family member 3
TRIM37 tripartite motif containing 37
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
ALOX15B arachidonate 15-lipoxygenase, type B
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BHLHE41 basic helix-loop-helix family, member e41
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CDC20 cell division cycle 20
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CREG1 cellular repressor of E1A-stimulated genes 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN1 fibrillin 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FZD6 frizzled class receptor 6
GJA1 gap junction protein, alpha 1, 43kDa
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
NEK2 NIMA-related kinase 2
NID2 nidogen 2 (osteonidogen)
NLRP2 NLR family, pyrin domain containing 2
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PSAT1 phosphoserine aminotransferase 1