BRD-K86797399_pracinostat_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K86797399_pracinostat_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ARMCX1 armadillo repeat containing, X-linked 1
BLVRA biliverdin reductase A
CCND1 cyclin D1
CCNG2 cyclin G2
CD24 CD24 molecule
CLEC3B C-type lectin domain family 3, member B
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSRP1 cysteine and glycine-rich protein 1
CTSA cathepsin A
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F13A1 coagulation factor XIII, A1 polypeptide
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO4 forkhead box O4
FRZB frizzled-related protein
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
IDS iduronate 2-sulfatase
ISYNA1 inositol-3-phosphate synthase 1
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC16A leucine rich repeat containing 16A
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MT1F metallothionein 1F
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPTX2 neuronal pentraxin II
NSG1 neuron specific gene family member 1
OPTN optineurin
PFKM phosphofructokinase, muscle
PRAF2 PRA1 domain family, member 2
PRAME preferentially expressed antigen in melanoma
PRDX2 peroxiredoxin 2
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RAB13 RAB13, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RBP1 retinol binding protein 1, cellular
RGS20 regulator of G-protein signaling 20
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SFRP1 secreted frizzled-related protein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SQSTM1 sequestosome 1
TMEM135 transmembrane protein 135
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WBP5 WW domain binding protein 5
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
CD48 CD48 molecule
CDC42 cell division cycle 42
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DLC1 DLC1 Rho GTPase activating protein
DPYSL3 dihydropyrimidinase-like 3
EIF4A1 eukaryotic translation initiation factor 4A1
ESRP1 epithelial splicing regulatory protein 1
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KCTD12 potassium channel tetramerization domain containing 12
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
LMNB1 lamin B1
LTF lactotransferrin
MINA MYC induced nuclear antigen
MSMB microseminoprotein, beta-
NACA nascent polypeptide-associated complex alpha subunit
NID2 nidogen 2 (osteonidogen)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
RPIA ribose 5-phosphate isomerase A
RPL10 ribosomal protein L10
RPP38 ribonuclease P/MRP 38kDa subunit
SIDT1 SID1 transmembrane family, member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLIT2 slit homolog 2 (Drosophila)
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
TAGLN transgelin
TARBP1 TAR (HIV-1) RNA binding protein 1
TARS threonyl-tRNA synthetase
TFF1 trefoil factor 1
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TRIO trio Rho guanine nucleotide exchange factor
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TWF1 twinfilin actin binding protein 1
XIST X inactive specific transcript (non-protein coding)