BRD-K86797399_pracinostat_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K86797399_pracinostat_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADGRE5 adhesion G protein-coupled receptor E5
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASPN asporin
CD9 CD9 molecule
CDC42 cell division cycle 42
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
FNDC3B fibronectin type III domain containing 3B
GOLM1 golgi membrane protein 1
GREM1 gremlin 1, DAN family BMP antagonist
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
IRS1 insulin receptor substrate 1
ISOC1 isochorismatase domain containing 1
JUNB jun B proto-oncogene
LRP10 low density lipoprotein receptor-related protein 10
LUM lumican
MAPT microtubule-associated protein tau
MEIS1 Meis homeobox 1
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPPED2 metallophosphoesterase domain containing 2
NCAM1 neural cell adhesion molecule 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PFKM phosphofructokinase, muscle
PLLP plasmolipin
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
S100A4 S100 calcium binding protein A4
SCPEP1 serine carboxypeptidase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VNN1 vanin 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATMIN ATM interactor
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1ORF115 chromosome 1 open reading frame 115
CCNA2 cyclin A2
CD99 CD99 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLEC3B C-type lectin domain family 3, member B
CNR1 cannabinoid receptor 1 (brain)
CSNK1A1 casein kinase 1, alpha 1
CTSH cathepsin H
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCLK1 doublecortin-like kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
ECH1 enoyl CoA hydratase 1, peroxisomal
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX3 epoxide hydrolase 3
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IRAK1 interleukin-1 receptor-associated kinase 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM5D lysine (K)-specific demethylase 5D
LMO3 LIM domain only 3 (rhombotin-like 2)
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PPIF peptidylprolyl isomerase F
SELENBP1 selenium binding protein 1
SFTPB surfactant protein B
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
TCF4 transcription factor 4
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZBTB18 zinc finger and BTB domain containing 18