BRD-K86797399_pracinostat_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K86797399_pracinostat_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
AQP3 aquaporin 3 (Gill blood group)
BACE2 beta-site APP-cleaving enzyme 2
BEX4 brain expressed, X-linked 4
BMP7 bone morphogenetic protein 7
CD36 CD36 molecule (thrombospondin receptor)
CLEC2B C-type lectin domain family 2, member B
COL6A1 collagen, type VI, alpha 1
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
FYB FYN binding protein
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HK1 hexokinase 1
IL7R interleukin 7 receptor
KCTD5 potassium channel tetramerization domain containing 5
LAPTM4B lysosomal protein transmembrane 4 beta
LEPROTL1 leptin receptor overlapping transcript-like 1
LPAR6 lysophosphatidic acid receptor 6
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMD monocyte to macrophage differentiation-associated
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEFL neurofilament, light polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLP1 proteolipid protein 1
PLVAP plasmalemma vesicle associated protein
PNP purine nucleoside phosphorylase
PRAF2 PRA1 domain family, member 2
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A46 solute carrier family 25, member 46
SST somatostatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TKTL1 transketolase-like 1
TSPYL4 TSPY-like 4
UGT8 UDP glycosyltransferase 8
VCAN versican
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
ASXL2 additional sex combs like transcriptional regulator 2
CAPN1 calpain 1, (mu/I) large subunit
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKS1B CDC28 protein kinase regulatory subunit 1B
COL5A2 collagen, type V, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSH cathepsin H
DPT dermatopontin
FGFR2 fibroblast growth factor receptor 2
GSAP gamma-secretase activating protein
HOPX HOP homeobox
JUP junction plakoglobin
KIF14 kinesin family member 14
NFIB nuclear factor I/B
RELN reelin
RNH1 ribonuclease/angiogenin inhibitor 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B