BRD-K86797399_pracinostat_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K86797399_pracinostat_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT3 v-akt murine thymoma viral oncogene homolog 3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
CAV2 caveolin 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CHRDL1 chordin-like 1
CTSC cathepsin C
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FILIP1L filamin A interacting protein 1-like
FOXJ3 forkhead box J3
FYN FYN proto-oncogene, Src family tyrosine kinase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0485 uncharacterized LOC57235
LAMA3 laminin, alpha 3
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MITF microphthalmia-associated transcription factor
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
NEFL neurofilament, light polypeptide
OXA1L oxidase (cytochrome c) assembly 1-like
PALLD palladin, cytoskeletal associated protein
PCDH7 protocadherin 7
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PLN phospholamban
PLS1 plastin 1
PROM1 prominin 1
PTN pleiotrophin
RAB31 RAB31, member RAS oncogene family
RTN2 reticulon 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STON1 stonin 1
SYT1 synaptotagmin I
TGM2 transglutaminase 2
TMSB15A thymosin beta 15a
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TUBA4A tubulin, alpha 4a
VAT1 vesicle amine transport 1
VCAN versican
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CCL5 chemokine (C-C motif) ligand 5
CLTB clathrin, light chain B
CREB1 cAMP responsive element binding protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBRD1 cytochrome b reductase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
HLA-B major histocompatibility complex, class I, B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGB1BP1 integrin beta 1 binding protein 1
KDM5D lysine (K)-specific demethylase 5D
LOX lysyl oxidase
LRRC41 leucine rich repeat containing 41
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NGRN neugrin, neurite outgrowth associated
NKX3-1 NK3 homeobox 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RPS4Y1 ribosomal protein S4, Y-linked 1
RTP4 receptor (chemosensory) transporter protein 4
SDC4 syndecan 4
SH3YL1 SH3 and SYLF domain containing 1
TM9SF3 transmembrane 9 superfamily member 3
TNPO1 transportin 1
TP53 tumor protein p53
ZNF91 zinc finger protein 91