BRD-K86797399_pracinostat_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

297 genes differentially expressed following the BRD-K86797399_pracinostat_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIRF adipogenesis regulatory factor
AHR aryl hydrocarbon receptor
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARG2 arginase 2
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BLNK B-cell linker
BTBD3 BTB (POZ) domain containing 3
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNA1 cyclin A1
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDR2L cerebellar degeneration-related protein 2-like
CFD complement factor D (adipsin)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTB clathrin, light chain B
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CSTA cystatin A (stefin A)
CTSB cathepsin B
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DNM3 dynamin 3
DUSP14 dual specificity phosphatase 14
EFNA1 ephrin-A1
EZR ezrin
F11R F11 receptor
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBXO2 F-box protein 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNS glucosamine (N-acetyl)-6-sulfatase
GOLGA8A golgin A8 family, member A
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GRN granulin
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HDAC5 histone deacetylase 5
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HK1 hexokinase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF2R insulin-like growth factor 2 receptor
INPP1 inositol polyphosphate-1-phosphatase
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
L1CAM L1 cell adhesion molecule
LIPA lipase A, lysosomal acid, cholesterol esterase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OAT ornithine aminotransferase
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G15 phospholipase A2, group XV
POR P450 (cytochrome) oxidoreductase
PRSS2 protease, serine, 2 (trypsin 2)
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RGS10 regulator of G-protein signaling 10
RHOA ras homolog family member A
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RTN2 reticulon 2
SARAF store-operated calcium entry-associated regulatory factor
SCPEP1 serine carboxypeptidase 1
SERINC3 serine incorporator 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFXN3 sideroflexin 3
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORT1 sortilin 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
STAR steroidogenic acute regulatory protein
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTA T-cell leukemia translocation altered
TES testin LIM domain protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMC6 transmembrane channel-like 6
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
AGR2 anterior gradient 2
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
CTBP1 C-terminal binding protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDN1 endothelin 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
EXO1 exonuclease 1
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GOLM1 golgi membrane protein 1
GSAP gamma-secretase activating protein
GTSE1 G-2 and S-phase expressed 1
HDDC2 HD domain containing 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
IDO1 indoleamine 2,3-dioxygenase 1
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IPO5 importin 5
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KIAA0368 KIAA0368
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KLK11 kallikrein-related peptidase 11
LHX2 LIM homeobox 2
LMNB1 lamin B1
LMNB2 lamin B2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC41 leucine rich repeat containing 41
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MLPH melanophilin
MOXD1 monooxygenase, DBH-like 1
MRPL15 mitochondrial ribosomal protein L15
MTERF3 mitochondrial transcription termination factor 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PARVB parvin, beta
PAX6 paired box 6
PBK PDZ binding kinase
PFAS phosphoribosylformylglycinamidine synthase
PGD phosphogluconate dehydrogenase
PHF11 PHD finger protein 11
PLBD1 phospholipase B domain containing 1
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
SCUBE2 signal peptide, CUB domain, EGF-like 2
SENP6 SUMO1/sentrin specific peptidase 6
SHCBP1 SHC SH2-domain binding protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SORBS3 sorbin and SH3 domain containing 3
SPAG7 sperm associated antigen 7
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TP53 tumor protein p53
TRD T cell receptor delta locus
TRIP13 thyroid hormone receptor interactor 13
TSKU tsukushi, small leucine rich proteoglycan
TTN titin
TUBB6 tubulin, beta 6 class V
TWIST1 twist family bHLH transcription factor 1
UBE2C ubiquitin-conjugating enzyme E2C
VAV3 vav 3 guanine nucleotide exchange factor
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBED1 zinc finger, BED-type containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZWINT ZW10 interacting kinetochore protein