BRD-K86761848_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K86761848_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CPD carboxypeptidase D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
FADS1 fatty acid desaturase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIK1 salt-inducible kinase 1
SLC16A4 solute carrier family 16, member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX4 SRY (sex determining region Y)-box 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
BAX BCL2-associated X protein
CA2 carbonic anhydrase II
CNPY3 canopy FGF signaling regulator 3
CXCL12 chemokine (C-X-C motif) ligand 12
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOLR1 folate receptor 1 (adult)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
MXRA5 matrix-remodelling associated 5
NELL2 NEL-like 2 (chicken)
NT5DC2 5'-nucleotidase domain containing 2
SATB2 SATB homeobox 2
SELENBP1 selenium binding protein 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TM9SF2 transmembrane 9 superfamily member 2
TUBB6 tubulin, beta 6 class V
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon