BRD-K86761848_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K86761848_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PER1 period circadian clock 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PTBP2 polypyrimidine tract binding protein 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RIOK3 RIO kinase 3
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA6 annexin A6
B3GNT1
CDC42 cell division cycle 42
ERBB2 erb-b2 receptor tyrosine kinase 2
FLNA filamin A, alpha
FXYD5 FXYD domain containing ion transport regulator 5
HN1 hematological and neurological expressed 1
HSPA8 heat shock 70kDa protein 8
LMO2 LIM domain only 2 (rhombotin-like 1)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
OXA1L oxidase (cytochrome c) assembly 1-like
PGK1 phosphoglycerate kinase 1
RTN2 reticulon 2
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble