BRD-K86574132_-666_SW620_6.0_h_48.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K86574132_-666_SW620_6.0_h_48.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA11 annexin A11
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
COL5A2 collagen, type V, alpha 2
CRCT1 cysteine-rich C-terminal 1
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAL histidine ammonia-lyase
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
INPP1 inositol polyphosphate-1-phosphatase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LAMA3 laminin, alpha 3
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PRSS23 protease, serine, 23
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCEL sciellin
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIK1 salt-inducible kinase 1
SPON2 spondin 2, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOB1 transducer of ERBB2, 1
TRIB3 tribbles pseudokinase 3
TSPAN1 tetraspanin 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CCNB1 cyclin B1
CCNF cyclin F
CD14 CD14 molecule
CD200 CD200 molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CSRP2 cysteine and glycine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYC1 cytochrome c-1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
GAS2L1 growth arrest-specific 2 like 1
GMFG glia maturation factor, gamma
GTSE1 G-2 and S-phase expressed 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL32 interleukin 32
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LMO2 LIM domain only 2 (rhombotin-like 1)
MAOB monoamine oxidase B
NES nestin
OXA1L oxidase (cytochrome c) assembly 1-like
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TBC1D4 TBC1 domain family, member 4
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMPRSS3 transmembrane protease, serine 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
USP22 ubiquitin specific peptidase 22
WFS1 Wolfram syndrome 1 (wolframin)