BRD-K86574132_-666_MCF7_6.0_h_48.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K86574132_-666_MCF7_6.0_h_48.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG1 adhesion G protein-coupled receptor G1
ANXA4 annexin A4
APOLD1 apolipoprotein L domain containing 1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
ENO2 enolase 2 (gamma, neuronal)
ERP29 endoplasmic reticulum protein 29
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FLOT1 flotillin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS7 growth arrest-specific 7
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
MAP1B microtubule-associated protein 1B
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PENK proenkephalin
PER1 period circadian clock 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAP prosaposin
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
STC2 stanniocalcin 2
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TP53 tumor protein p53
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZNF131 zinc finger protein 131
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
CD58 CD58 molecule
CDC25A cell division cycle 25A
CFH complement factor H
COL4A5 collagen, type IV, alpha 5
CRISP3 cysteine-rich secretory protein 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYD dihydropyrimidine dehydrogenase
FAM3C family with sequence similarity 3, member C
FASTKD5 FAST kinase domains 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GUSBP11 glucuronidase, beta pseudogene 11
HHEX hematopoietically expressed homeobox
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PID1 phosphotyrosine interaction domain containing 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PPIF peptidylprolyl isomerase F
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PVALB parvalbumin
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SFPQ splicing factor proline/glutamine-rich
SH3BGRL SH3 domain binding glutamate-rich protein like
SLBP stem-loop binding protein
SPINK1 serine peptidase inhibitor, Kazal type 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
ZCCHC2 zinc finger, CCHC domain containing 2