BRD-K86574132_-666_HA1E_6.0_h_48.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K86574132_-666_HA1E_6.0_h_48.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BMP6 bone morphogenetic protein 6
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EZR ezrin
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NLRP2 NLR family, pyrin domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
SARS seryl-tRNA synthetase
SCG5 secretogranin V
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
SYNJ2 synaptojanin 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
CFI complement factor I
DEFB1 defensin, beta 1
IDI1 isopentenyl-diphosphate delta isomerase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
S100A2 S100 calcium binding protein A2