BRD-K86492010_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K86492010_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZU1 azurocidin 1
BTG1 B-cell translocation gene 1, anti-proliferative
C1S complement component 1, s subcomponent
CARS cysteinyl-tRNA synthetase
CDK6 cyclin-dependent kinase 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
E2F2 E2F transcription factor 2
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
KRT19 keratin 19, type I
LCN2 lipocalin 2
LHFPL2 lipoma HMGIC fusion partner-like 2
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
MAN1A1 mannosidase, alpha, class 1A, member 1
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MPO myeloperoxidase
MSLN mesothelin
NUCB2 nucleobindin 2
OSR2 odd-skipped related transciption factor 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTGES prostaglandin E synthase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN7 tetraspanin 7
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADCY1 adenylate cyclase 1 (brain)
ADM adrenomedullin
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CD200 CD200 molecule
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
DPYSL2 dihydropyrimidinase-like 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGL2 fibrinogen-like 2
GCH1 GTP cyclohydrolase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
INSIG1 insulin induced gene 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PHACTR2 phosphatase and actin regulator 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFTPA2 surfactant protein A2
SPINK5 serine peptidase inhibitor, Kazal type 5