BRD-K86027709_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K86027709_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD6 abhydrolase domain containing 6
ADGRA2 adhesion G protein-coupled receptor A2
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHA4 EPH receptor A4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLRX glutaredoxin (thioltransferase)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
JAK1 Janus kinase 1
KLF2 Kruppel-like factor 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LST1 leukocyte specific transcript 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LXN latexin
MAPT microtubule-associated protein tau
MCAM melanoma cell adhesion molecule
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MSN moesin
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PFKM phosphofructokinase, muscle
PGF placental growth factor
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PRKCB protein kinase C, beta
PRR15L proline rich 15-like
PTN pleiotrophin
RAB29 RAB29, member RAS oncogene family
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
SCG5 secretogranin V
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPON1 spondin 1, extracellular matrix protein
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176A transmembrane protein 176A
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CNPY3 canopy FGF signaling regulator 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ELANE elastase, neutrophil expressed
ELF5 E74-like factor 5 (ets domain transcription factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FST follistatin
HBEGF heparin-binding EGF-like growth factor
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT16 keratin 16, type I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MFAP5 microfibrillar associated protein 5
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
RALGDS ral guanine nucleotide dissociation stimulator
SLPI secretory leukocyte peptidase inhibitor
TAGLN transgelin
TLR4 toll-like receptor 4