BRD-K86027709_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K86027709_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
C14ORF132 chromosome 14 open reading frame 132
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL1A1 collagen, type I, alpha 1
CORO1A coronin, actin binding protein, 1A
CSRP1 cysteine and glycine-rich protein 1
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGBP Fc fragment of IgG binding protein
FLNA filamin A, alpha
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
FXYD6 FXYD domain containing ion transport regulator 6
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GPR161 G protein-coupled receptor 161
HEPH hephaestin
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
ISG15 ISG15 ubiquitin-like modifier
ISLR immunoglobulin superfamily containing leucine-rich repeat
JAG1 jagged 1
KDM5B lysine (K)-specific demethylase 5B
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
MFAP2 microfibrillar-associated protein 2
MMD monocyte to macrophage differentiation-associated
MSX1 msh homeobox 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYH11 myosin, heavy chain 11, smooth muscle
NDRG1 N-myc downstream regulated 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROCR protein C receptor, endothelial
PYGL phosphorylase, glycogen, liver
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SFRP4 secreted frizzled-related protein 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TWF2 twinfilin actin binding protein 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATF5 activating transcription factor 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CENPU centromere protein U
DCK deoxycytidine kinase
DUT deoxyuridine triphosphatase
FANCI Fanconi anemia, complementation group I
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
ICAM3 intercellular adhesion molecule 3
ING3 inhibitor of growth family, member 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MSMB microseminoprotein, beta-
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP85 nucleoporin 85kDa
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDCD2 programmed cell death 2
PPIF peptidylprolyl isomerase F
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase