BRD-K86027709_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K86027709_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FADS2 fatty acid desaturase 2
H1F0 H1 histone family, member 0
IER3 immediate early response 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
ISG15 ISG15 ubiquitin-like modifier
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
MXRA7 matrix-remodelling associated 7
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLIN2 perilipin 2
PNMA2 paraneoplastic Ma antigen 2
PRKCA protein kinase C, alpha
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SYNM synemin, intermediate filament protein
TM4SF1 transmembrane 4 L six family member 1
TMEM106C transmembrane protein 106C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
BZW2 basic leucine zipper and W2 domains 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CXCL9 chemokine (C-X-C motif) ligand 9
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
FAM57A family with sequence similarity 57, member A
MCOLN1 mucolipin 1
NXN nucleoredoxin
SPTSSA serine palmitoyltransferase, small subunit A
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)