BRD-K85985071_E3380_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K85985071_E3380_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AGRN agrin
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARHGAP32 Rho GTPase activating protein 32
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CAV2 caveolin 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD24 CD24 molecule
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLCA2 chloride channel accessory 2
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CST1 cystatin SN
CTAG2 cancer/testis antigen 2
CTSZ cathepsin Z
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP8 dipeptidyl-peptidase 8
DSP desmoplakin
DST dystonin
DUSP4 dual specificity phosphatase 4
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL2 FOS-like antigen 2
FRY furry homolog (Drosophila)
FXYD3 FXYD domain containing ion transport regulator 3
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAGE3 G antigen 3
GATA2 GATA binding protein 2
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GPR161 G protein-coupled receptor 161
GPR87 G protein-coupled receptor 87
GRN granulin
HCAR3 hydroxycarboxylic acid receptor 3
HIST2H2BE histone cluster 2, H2be
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT20 keratin 20, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL1 lysyl oxidase-like 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAGEA4 melanoma antigen family A4
MAOA monoamine oxidase A
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCF2 neutrophil cytosolic factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
OLFM4 olfactomedin 4
OPTN optineurin
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PINK1 PTEN induced putative kinase 1
PLAU plasminogen activator, urokinase
PLXNA1 plexin A1
PLXNB2 plexin B2
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SOCS2 suppressor of cytokine signaling 2
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
SYNGR1 synaptogyrin 1
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP2 TIMP metallopeptidase inhibitor 2
TOP1 topoisomerase (DNA) I
TP63 tumor protein p63
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TREM1 triggering receptor expressed on myeloid cells 1
TRIM29 tripartite motif containing 29
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCL vinculin
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK1 adenylate kinase 1
AMD1 adenosylmethionine decarboxylase 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARMCX6 armadillo repeat containing, X-linked 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C12ORF29 chromosome 12 open reading frame 29
C2CD5 C2 calcium-dependent domain containing 5
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CFH complement factor H
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CRYZ crystallin, zeta (quinone reductase)
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ELP5 elongator acetyltransferase complex subunit 5
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM35A family with sequence similarity 35, member A
FAM63A family with sequence similarity 63, member A
FAM64A family with sequence similarity 64, member A
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMFB glia maturation factor, beta
H2AFZ H2A histone family, member Z
HLTF helicase-like transcription factor
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IARS isoleucyl-tRNA synthetase
ICAM3 intercellular adhesion molecule 3
IFI44 interferon-induced protein 44
IFITM2 interferon induced transmembrane protein 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAGE3 L antigen family, member 3
LAMP5 lysosomal-associated membrane protein family, member 5
LEPR leptin receptor
LMNB1 lamin B1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCTS1 malignant T cell amplified sequence 1
MELK maternal embryonic leucine zipper kinase
MRPS30 mitochondrial ribosomal protein S30
MTERF3 mitochondrial transcription termination factor 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NHP2 NHP2 ribonucleoprotein
NIT2 nitrilase family, member 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NPM3 nucleophosmin/nucleoplasmin 3
ORC5 origin recognition complex, subunit 5
PAK1IP1 PAK1 interacting protein 1
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRC1 protein regulator of cytokinesis 1
PRDX4 peroxiredoxin 4
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTDSS1 phosphatidylserine synthase 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RACGAP1 Rac GTPase activating protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFK riboflavin kinase
RNASE4 ribonuclease, RNase A family, 4
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RPS5 ribosomal protein S5
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SDC2 syndecan 2
SEH1L SEH1-like (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SET SET nuclear proto-oncogene
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARS threonyl-tRNA synthetase
TFAM transcription factor A, mitochondrial
TFF1 trefoil factor 1
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TPX2 TPX2, microtubule-associated
TRAPPC4 trafficking protein particle complex 4
TTK TTK protein kinase
TUBB tubulin, beta class I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
WDR12 WD repeat domain 12
XPOT exportin, tRNA