BRD-K85606544_neratinib_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K85606544_neratinib_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD9 CD9 molecule
CNN3 calponin 3, acidic
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EMP1 epithelial membrane protein 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLOT1 flotillin 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
LOC100272216 uncharacterized LOC100272216
LPAR1 lysophosphatidic acid receptor 1
MMP9 matrix metallopeptidase 9
MVP major vault protein
NARFL nuclear prelamin A recognition factor-like
NDRG1 N-myc downstream regulated 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PHGDH phosphoglycerate dehydrogenase
PNKP polynucleotide kinase 3'-phosphatase
PTCH1 patched 1
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TPP1 tripeptidyl peptidase I
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CPE carboxypeptidase E
DLK1 delta-like 1 homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GTSE1 G-2 and S-phase expressed 1
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
LARP1 La ribonucleoprotein domain family, member 1
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PBK PDZ binding kinase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
SHB Src homology 2 domain containing adaptor protein B
SPRR1A small proline-rich protein 1A
STMN1 stathmin 1
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
VCAN versican