BRD-K85606544_neratinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K85606544_neratinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTC1 actin, alpha, cardiac muscle 1
ADGRG6 adhesion G protein-coupled receptor G6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPE carboxypeptidase E
CREB3L2 cAMP responsive element binding protein 3-like 2
CRYAB crystallin, alpha B
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DOK5 docking protein 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FAM129A family with sequence similarity 129, member A
FERMT2 fermitin family member 2
FRZB frizzled-related protein
GARS glycyl-tRNA synthetase
IDO1 indoleamine 2,3-dioxygenase 1
KDM5D lysine (K)-specific demethylase 5D
KLK5 kallikrein-related peptidase 5
LXN latexin
MAST4 microtubule associated serine/threonine kinase family member 4
MDFIC MyoD family inhibitor domain containing
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
RAB31 RAB31, member RAS oncogene family
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SST somatostatin
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WWC3 WWC family member 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CCL20 chemokine (C-C motif) ligand 20
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL27RA interleukin 27 receptor, alpha
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LUM lumican
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYB v-myb avian myeloblastosis viral oncogene homolog
NPR3 natriuretic peptide receptor 3
OLFM4 olfactomedin 4
OPN3 opsin 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALLD palladin, cytoskeletal associated protein
PLCB4 phospholipase C, beta 4
RBPMS RNA binding protein with multiple splicing
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMC1A structural maintenance of chromosomes 1A
SPP1 secreted phosphoprotein 1
TBX3 T-box 3
TFRC transferrin receptor
THBS1 thrombospondin 1
TRH thyrotropin-releasing hormone
WFDC2 WAP four-disulfide core domain 2