BRD-K85606544_neratinib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K85606544_neratinib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
BTG1 B-cell translocation gene 1, anti-proliferative
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DSC3 desmocollin 3
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EDNRB endothelin receptor type B
EMP2 epithelial membrane protein 2
GHR growth hormone receptor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX3 glutathione peroxidase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFT57 intraflagellar transport 57
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF2 Kruppel-like factor 2
LY6D lymphocyte antigen 6 complex, locus D
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
SDC2 syndecan 2
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STAR steroidogenic acute regulatory protein
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNNC1 troponin C type 1 (slow)
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANPEP alanyl (membrane) aminopeptidase
BHLHE40 basic helix-loop-helix family, member e40
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD9 CD9 molecule
CDCP1 CUB domain containing protein 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV5 ets variant 5
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSX1 msh homeobox 1
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
RGS10 regulator of G-protein signaling 10
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L2 tumor protein D52-like 2
TRIB3 tribbles pseudokinase 3