BRD-K85606544_neratinib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K85606544_neratinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
C2CD2 C2 calcium-dependent domain containing 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIT citron rho-interacting serine/threonine kinase
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSL cathepsin L
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
FAM107A family with sequence similarity 107, member A
FAM13A family with sequence similarity 13, member A
HBB hemoglobin, beta
IGKV4-1 immunoglobulin kappa variable 4-1
MYBPC1 myosin binding protein C, slow type
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOTCH3 notch 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P3H2 prolyl 3-hydroxylase 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS3 sorbin and SH3 domain containing 3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TSC22D3 TSC22 domain family, member 3
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALB albumin
ARG1 arginase 1
BID BH3 interacting domain death agonist
C3 complement component 3
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CFI complement factor I
CXCL12 chemokine (C-X-C motif) ligand 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DIO1 deiodinase, iodothyronine, type I
DPYD dihydropyrimidine dehydrogenase
EI24 etoposide induced 2.4
EIF4A1 eukaryotic translation initiation factor 4A1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
LIPG lipase, endothelial
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
NDP Norrie disease (pseudoglioma)
PLAT plasminogen activator, tissue
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SFRP1 secreted frizzled-related protein 1
SQLE squalene epoxidase