BRD-K85606544_neratinib_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K85606544_neratinib_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADAM28 ADAM metallopeptidase domain 28
ADGRG1 adhesion G protein-coupled receptor G1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANGPT1 angiopoietin 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLVRB biliverdin reductase B
CBS cystathionine-beta-synthase
CD44 CD44 molecule (Indian blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
DUSP22 dual specificity phosphatase 22
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FAM46C family with sequence similarity 46, member C
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
IGKV1-5 immunoglobulin kappa variable 1-5
INTS3 integrator complex subunit 3
IRF9 interferon regulatory factor 9
ITGB4 integrin, beta 4
JCHAIN joining chain of multimeric IgA and IgM
KIAA0125 KIAA0125
LAMA3 laminin, alpha 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MICALL1 MICAL-like 1
MNDA myeloid cell nuclear differentiation antigen
MSRB2 methionine sulfoxide reductase B2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFML2A olfactomedin-like 2A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIR pirin (iron-binding nuclear protein)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAB13 RAB13, member RAS oncogene family
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFF3 trefoil factor 3 (intestinal)
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ARL4C ADP-ribosylation factor-like 4C
BRCA1 breast cancer 1, early onset
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTPS1 CTP synthase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
INHBA inhibin, beta A
KIF18B kinesin family member 18B
KIF1BP KIF1 binding protein
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
NET1 neuroepithelial cell transforming 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERINC5 serine incorporator 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SRSF1 serine/arginine-rich splicing factor 1
SRSF6 serine/arginine-rich splicing factor 6
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TSPYL5 TSPY-like 5
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
ZWINT ZW10 interacting kinetochore protein