BRD-K85606544_neratinib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

213 genes differentially expressed following the BRD-K85606544_neratinib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ADGRG1 adhesion G protein-coupled receptor G1
ADIRF adipogenesis regulatory factor
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPTL2 angiopoietin-like 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX1 brain expressed, X-linked 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CCNI cyclin I
CD163 CD163 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CTBS chitobiase, di-N-acetyl-
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DIAPH2 diaphanous-related formin 2
DSTN destrin (actin depolymerizing factor)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GSE1 Gse1 coiled-coil protein
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
KAT6B K(lysine) acetyltransferase 6B
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LRRC8D leucine rich repeat containing 8 family, member D
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PPIB peptidylprolyl isomerase B (cyclophilin B)
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RHOB ras homolog family member B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SARS seryl-tRNA synthetase
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
TCTA T-cell leukemia translocation altered
THBS4 thrombospondin 4
TP53I3 tumor protein p53 inducible protein 3
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF4A1 eukaryotic translation initiation factor 4A1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HSPA2 heat shock 70kDa protein 2
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
KIAA0226L KIAA0226-like
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT6B keratin 6B, type II
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LUM lumican
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MED21 mediator complex subunit 21
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MREG melanoregulin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NASP nuclear autoantigenic sperm protein (histone-binding)
NOP2 NOP2 nucleolar protein
NPAS2 neuronal PAS domain protein 2
NUSAP1 nucleolar and spindle associated protein 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLQ polymerase (DNA directed), theta
PRC1 protein regulator of cytokinesis 1
PRKD3 protein kinase D3
PSPH phosphoserine phosphatase
RAD51AP1 RAD51 associated protein 1
RECQL RecQ helicase-like
RFC3 replication factor C (activator 1) 3, 38kDa
RFWD3 ring finger and WD repeat domain 3
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TSPAN13 tetraspanin 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UGCG UDP-glucose ceramide glucosyltransferase
UNG uracil-DNA glycosylase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein