BRD-K85606544_neratinib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K85606544_neratinib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL6 B-cell CLL/lymphoma 6
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CCDC69 coiled-coil domain containing 69
CD40 CD40 molecule, TNF receptor superfamily member 5
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTSA cathepsin A
CTSB cathepsin B
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DUSP1 dual specificity phosphatase 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FHL1 four and a half LIM domains 1
GM2A GM2 ganglioside activator
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
H1F0 H1 histone family, member 0
HIST1H2AC histone cluster 1, H2ac
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT5 keratin 5, type II
LAMP2 lysosomal-associated membrane protein 2
LITAF lipopolysaccharide-induced TNF factor
MAGED1 melanoma antigen family D1
METRN meteorin, glial cell differentiation regulator
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MXRA7 matrix-remodelling associated 7
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G16 phospholipase A2, group XVI
PSAP prosaposin
PXDC1 PX domain containing 1
RABAC1 Rab acceptor 1 (prenylated)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SORBS2 sorbin and SH3 domain containing 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON2 spondin 2, extracellular matrix protein
TAGLN transgelin
TCTA T-cell leukemia translocation altered
TM7SF2 transmembrane 7 superfamily member 2
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
TYMP thymidine phosphorylase
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPN centromere protein N
CENPU centromere protein U
CLC Charcot-Leyden crystal galectin
COL3A1 collagen, type III, alpha 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER3 immediate early response 3
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OLFM1 olfactomedin 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TRIP13 thyroid hormone receptor interactor 13
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein