BRD-K85606544_neratinib_BT20_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

60 genes differentially expressed following the BRD-K85606544_neratinib_BT20_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ASNS asparagine synthetase (glutamine-hydrolyzing)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
FKBP11 FK506 binding protein 11, 19 kDa
FRZB frizzled-related protein
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCAR3 hydroxycarboxylic acid receptor 3
IFI27 interferon, alpha-inducible protein 27
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MUC4 mucin 4, cell surface associated
NKG7 natural killer cell granule protein 7
PCDH7 protocadherin 7
SELENBP1 selenium binding protein 1
SLC38A2 solute carrier family 38, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADCY1 adenylate cyclase 1 (brain)
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
CTGF connective tissue growth factor
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
MGP matrix Gla protein
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RGS10 regulator of G-protein signaling 10
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SFRP1 secreted frizzled-related protein 1
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
VAMP8 vesicle-associated membrane protein 8