BRD-K85606544_neratinib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

51 genes differentially expressed following the BRD-K85606544_neratinib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
CST3 cystatin C
CSTA cystatin A (stefin A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
HIST1H3H histone cluster 1, H3h
HLA-DMA major histocompatibility complex, class II, DM alpha
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
LRMP lymphoid-restricted membrane protein
LYZ lysozyme
MAN2B1 mannosidase, alpha, class 2B, member 1
NDRG1 N-myc downstream regulated 1
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD44 CD44 molecule (Indian blood group)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DUSP4 dual specificity phosphatase 4
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FOSL1 FOS-like antigen 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
LDHB lactate dehydrogenase B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
NFIB nuclear factor I/B
PHLDA2 pleckstrin homology-like domain, family A, member 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)