BRD-K85402309_dovitinib_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K85402309_dovitinib_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABR active BCR-related
ALOX5 arachidonate 5-lipoxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSG3 desmoglein 3
EHD3 EH-domain containing 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
GJA1 gap junction protein, alpha 1, 43kDa
HCAR3 hydroxycarboxylic acid receptor 3
HEPH hephaestin
HOPX HOP homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
KRT15 keratin 15, type I
KRT4 keratin 4, type II
LMO4 LIM domain only 4
MYBPC1 myosin binding protein C, slow type
NRGN neurogranin (protein kinase C substrate, RC3)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS13 regulator of G-protein signaling 13
S100A14 S100 calcium binding protein A14
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STK24 serine/threonine kinase 24
TF transferrin
TM4SF1 transmembrane 4 L six family member 1
WIF1 WNT inhibitory factor 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
CALML5 calmodulin-like 5
CD46 CD46 molecule, complement regulatory protein
CD93 CD93 molecule
COL15A1 collagen, type XV, alpha 1
COMP cartilage oligomeric matrix protein
DEGS1 delta(4)-desaturase, sphingolipid 1
FAM134B family with sequence similarity 134, member B
FASTKD5 FAST kinase domains 5
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HSPA1A heat shock 70kDa protein 1A
KIAA1033 KIAA1033
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
MTUS1 microtubule associated tumor suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NVL nuclear VCP-like
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPW1 selenoprotein W, 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)