BRD-K85402309_dovitinib_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K85402309_dovitinib_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALB albumin
C10ORF10 chromosome 10 open reading frame 10
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLDN7 claudin 7
COL15A1 collagen, type XV, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FCMR Fc fragment of IgM receptor
FLRT2 fibronectin leucine rich transmembrane protein 2
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GSTM3 glutathione S-transferase mu 3 (brain)
IDO1 indoleamine 2,3-dioxygenase 1
IGL immunoglobulin lambda locus
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MAGEA3 melanoma antigen family A3
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
PEG3 paternally expressed 3
PPAP2B phosphatidic acid phosphatase type 2B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOBP sine oculis binding protein homolog (Drosophila)
STAR steroidogenic acute regulatory protein
TGFBR3 transforming growth factor, beta receptor III
YBX3 Y box binding protein 3
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CAB39 calcium binding protein 39
EFNB2 ephrin-B2
EREG epiregulin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
KIAA0125 KIAA0125
KLF10 Kruppel-like factor 10
MARCKS myristoylated alanine-rich protein kinase C substrate
MYH10 myosin, heavy chain 10, non-muscle
NR1D2 nuclear receptor subfamily 1, group D, member 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
QDPR quinoid dihydropteridine reductase
THBS1 thrombospondin 1
TSPAN13 tetraspanin 13