BRD-K85402309_dovitinib_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K85402309_dovitinib_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ANXA2 annexin A2
APOE apolipoprotein E
ASNS asparagine synthetase (glutamine-hydrolyzing)
BASP1 brain abundant, membrane attached signal protein 1
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLEC7A C-type lectin domain family 7, member A
COL21A1 collagen, type XXI, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
LRRC17 leucine rich repeat containing 17
LYN LYN proto-oncogene, Src family tyrosine kinase
MOK MOK protein kinase
NEFL neurofilament, light polypeptide
PCP4 Purkinje cell protein 4
RPL39L ribosomal protein L39-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TM4SF4 transmembrane 4 L six family member 4
TPD52L1 tumor protein D52-like 1
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein

decreased expression

Symbol Name
AREG amphiregulin
BST2 bone marrow stromal cell antigen 2
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
CREB1 cAMP responsive element binding protein 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EZR ezrin
FN1 fibronectin 1
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
KLF6 Kruppel-like factor 6
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MXRA5 matrix-remodelling associated 5
PEG10 paternally expressed 10
PROM1 prominin 1
PTBP1 polypyrimidine tract binding protein 1
RGCC regulator of cell cycle
S100A2 S100 calcium binding protein A2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TIMP3 TIMP metallopeptidase inhibitor 3
TRIL TLR4 interactor with leucine-rich repeats
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1