BRD-K85402309_dovitinib_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K85402309_dovitinib_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOE apolipoprotein E
ASS1 argininosuccinate synthase 1
CLU clusterin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
H1F0 H1 histone family, member 0
IL1R1 interleukin 1 receptor, type I
KLHL9 kelch-like family member 9
NUPR1 nuclear protein, transcriptional regulator, 1
PRKCH protein kinase C, eta
S100A10 S100 calcium binding protein A10
SLC39A14 solute carrier family 39 (zinc transporter), member 14
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBR3 carbonyl reductase 3
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHN1 chimerin 1
COL6A3 collagen, type VI, alpha 3
CREB1 cAMP responsive element binding protein 1
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD1 frizzled class receptor 1
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HOXA10 homeobox A10
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
KLF10 Kruppel-like factor 10
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NREP neuronal regeneration related protein
PDE4B phosphodiesterase 4B, cAMP-specific
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
POPDC3 popeye domain containing 3
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RHOH ras homolog family member H
RND3 Rho family GTPase 3
SEPT2 septin 2
SFN stratifin
SH2B3 SH2B adaptor protein 3
SHB Src homology 2 domain containing adaptor protein B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1