BRD-K85402309_dovitinib_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K85402309_dovitinib_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAM basal cell adhesion molecule (Lutheran blood group)
CD200 CD200 molecule
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNPY3 canopy FGF signaling regulator 3
COL18A1 collagen, type XVIII, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GSTM3 glutathione S-transferase mu 3 (brain)
KAZN kazrin, periplakin interacting protein
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF5C kinesin family member 5C
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LXN latexin
MAOB monoamine oxidase B
MATN2 matrilin 2
MSLN mesothelin
NUP210 nucleoporin 210kDa
NUPR1 nuclear protein, transcriptional regulator, 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
S100A8 S100 calcium binding protein A8
SLPI secretory leukocyte peptidase inhibitor
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADRB2 adrenoceptor beta 2, surface
ASPH aspartate beta-hydroxylase
BID BH3 interacting domain death agonist
CCL2 chemokine (C-C motif) ligand 2
CD36 CD36 molecule (thrombospondin receptor)
CHIC2 cysteine-rich hydrophobic domain 2
CTSC cathepsin C
DCLK1 doublecortin-like kinase 1
DLX2 distal-less homeobox 2
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GLIPR1 GLI pathogenesis-related 1
GPNMB glycoprotein (transmembrane) nmb
HHEX hematopoietically expressed homeobox
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LAPTM5 lysosomal protein transmembrane 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MGLL monoglyceride lipase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PON2 paraoxonase 2
PTPRC protein tyrosine phosphatase, receptor type, C
SASH1 SAM and SH3 domain containing 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRY2 sprouty homolog 2 (Drosophila)
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b