BRD-K85402309_dovitinib_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K85402309_dovitinib_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
BAMBI BMP and activin membrane-bound inhibitor
C7 complement component 7
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EHD3 EH-domain containing 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LOC100505650 uncharacterized LOC100505650
MPZL2 myelin protein zero-like 2
NCALD neurocalcin delta
PPL periplakin
PTCH1 patched 1
QPCT glutaminyl-peptide cyclotransferase
RBKS ribokinase
RRAGD Ras-related GTP binding D
SNAP25 synaptosomal-associated protein, 25kDa
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
VLDLR very low density lipoprotein receptor
WFDC1 WAP four-disulfide core domain 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD14 CD14 molecule
CREB1 cAMP responsive element binding protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR3 early growth response 3
FABP4 fatty acid binding protein 4, adipocyte
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
ISG15 ISG15 ubiquitin-like modifier
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
LAMB3 laminin, beta 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP9 matrix metallopeptidase 9
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLAUR plasminogen activator, urokinase receptor
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
SEPP1 selenoprotein P, plasma, 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TLR4 toll-like receptor 4