BRD-K85402309_dovitinib_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K85402309_dovitinib_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
APOE apolipoprotein E
C6ORF48 chromosome 6 open reading frame 48
CCL5 chemokine (C-C motif) ligand 5
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL14A1 collagen, type XIV, alpha 1
CRYAB crystallin, alpha B
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KANK1 KN motif and ankyrin repeat domains 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LITAF lipopolysaccharide-induced TNF factor
LMOD1 leiomodin 1 (smooth muscle)
MAOA monoamine oxidase A
MATN2 matrilin 2
MMP9 matrix metallopeptidase 9
MYH11 myosin, heavy chain 11, smooth muscle
NDN necdin, melanoma antigen (MAGE) family member
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEBP1 phosphatidylethanolamine binding protein 1
PRKCD protein kinase C, delta
SDC2 syndecan 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN2 stathmin 2
STOM stomatin
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
TFF3 trefoil factor 3 (intestinal)
TM4SF4 transmembrane 4 L six family member 4
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
XK X-linked Kx blood group

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AMD1 adenosylmethionine decarboxylase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AXL AXL receptor tyrosine kinase
CDC45 cell division cycle 45
CENPU centromere protein U
DENND1B DENN/MADD domain containing 1B
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP1 epithelial membrane protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MSLN mesothelin
NEBL nebulette
NET1 neuroepithelial cell transforming 1
NPTX2 neuronal pentraxin II
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
PRSS21 protease, serine, 21 (testisin)
RFC2 replication factor C (activator 1) 2, 40kDa
RGCC regulator of cell cycle
RIN2 Ras and Rab interactor 2
SLC25A46 solute carrier family 25, member 46
SUMO3 small ubiquitin-like modifier 3
TFAM transcription factor A, mitochondrial
TK1 thymidine kinase 1, soluble
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein