BRD-K85402309_dovitinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K85402309_dovitinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BBX bobby sox homolog (Drosophila)
BCL6 B-cell CLL/lymphoma 6
BPIFA1 BPI fold containing family A, member 1
C5AR1 complement component 5a receptor 1
C8ORF4 chromosome 8 open reading frame 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CSTA cystatin A (stefin A)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK4 dedicator of cytokinesis 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ERBB3 erb-b2 receptor tyrosine kinase 3
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
GREM1 gremlin 1, DAN family BMP antagonist
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
INHBA inhibin, beta A
KRT7 keratin 7, type II
KYNU kynureninase
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
RAB31 RAB31, member RAS oncogene family
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPG20 spastic paraplegia 20 (Troyer syndrome)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TWF2 twinfilin actin binding protein 2
VLDLR very low density lipoprotein receptor
WWOX WW domain containing oxidoreductase
YARS tyrosyl-tRNA synthetase
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CHEK2 checkpoint kinase 2
CLTB clathrin, light chain B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COPS7A COP9 signalosome subunit 7A
CRABP2 cellular retinoic acid binding protein 2
CST6 cystatin E/M
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
KIF20A kinesin family member 20A
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MSMO1 methylsterol monooxygenase 1
NPTX1 neuronal pentraxin I
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SPARCL1 SPARC-like 1 (hevin)
STMN1 stathmin 1
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein