BRD-K85402309_dovitinib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K85402309_dovitinib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTA1 actin, alpha 1, skeletal muscle
ADAM9 ADAM metallopeptidase domain 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CD52 CD52 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC3 chloride intracellular channel 3
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GALC galactosylceramidase
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOPX HOP homeobox
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
LDB3 LIM domain binding 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPO myeloperoxidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NARS asparaginyl-tRNA synthetase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC3 serine incorporator 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TCTA T-cell leukemia translocation altered
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VDAC1 voltage-dependent anion channel 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AFF1 AF4/FMR2 family, member 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CCP110 centriolar coiled coil protein 110kDa
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GOLT1B golgi transport 1B
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
NCAPG non-SMC condensin I complex, subunit G
NDP Norrie disease (pseudoglioma)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDE4B phosphodiesterase 4B, cAMP-specific
PGAM1 phosphoglycerate mutase 1 (brain)
PON2 paraoxonase 2
PRC1 protein regulator of cytokinesis 1
PTMA prothymosin, alpha
RAD51AP1 RAD51 associated protein 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SMC4 structural maintenance of chromosomes 4
SPDL1 spindle apparatus coiled-coil protein 1
SPON1 spondin 1, extracellular matrix protein
SSFA2 sperm specific antigen 2
STMN1 stathmin 1
STOM stomatin
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM45A transmembrane protein 45A
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein