BRD-K85402309_dovitinib_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K85402309_dovitinib_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CNN3 calponin 3, acidic
CX3CR1 chemokine (C-X3-C motif) receptor 1
DMD dystrophin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FKBP11 FK506 binding protein 11, 19 kDa
GLUL glutamate-ammonia ligase
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCAR3 hydroxycarboxylic acid receptor 3
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
LEPR leptin receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MMD monocyte to macrophage differentiation-associated
PDZD2 PDZ domain containing 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QKI QKI, KH domain containing, RNA binding
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TBL1X transducin (beta)-like 1X-linked
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
CD44 CD44 molecule (Indian blood group)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GLIPR1 GLI pathogenesis-related 1
HBEGF heparin-binding EGF-like growth factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP6 insulin-like growth factor binding protein 6
LAPTM4B lysosomal protein transmembrane 4 beta
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PLAC8 placenta-specific 8
PODXL podocalyxin-like
RAB25 RAB25, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1