BRD-K85402309_dovitinib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K85402309_dovitinib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCNG1 cyclin G1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FDXR ferredoxin reductase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXN3 forkhead box N3
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GM2A GM2 ganglioside activator
HIST1H2AC histone cluster 1, H2ac
IGHM immunoglobulin heavy constant mu
KRT14 keratin 14, type I
LDOC1 leucine zipper, down-regulated in cancer 1
MYLK myosin light chain kinase
NEBL nebulette
NXN nucleoredoxin
ORAI3 ORAI calcium release-activated calcium modulator 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIEZO2 piezo-type mechanosensitive ion channel component 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON2 paraoxonase 2
RBKS ribokinase
RBP4 retinol binding protein 4, plasma
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS27L ribosomal protein S27-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SESN1 sestrin 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SNAI2 snail family zinc finger 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53TG1 TP53 target 1 (non-protein coding)
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
VDAC1 voltage-dependent anion channel 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H1F0 H1 histone family, member 0
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
LYZ lysozyme
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MFAP2 microfibrillar-associated protein 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NDRG2 NDRG family member 2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPC25 SPC25, NDC80 kinetochore complex component
STIL SCL/TAL1 interrupting locus
TACC3 transforming, acidic coiled-coil containing protein 3
TPX2 TPX2, microtubule-associated
TRBC1 T cell receptor beta constant 1
TTK TTK protein kinase
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)