BRD-K85275009_methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate MAY_9_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K85275009_methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate MAY_9_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
ASPN asporin
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FZD10 frizzled class receptor 10
GPC3 glypican 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
KRT23 keratin 23, type I
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MEIS2 Meis homeobox 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NRGN neurogranin (protein kinase C substrate, RC3)
PDZK1IP1 PDZK1 interacting protein 1
PLVAP plasmalemma vesicle associated protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN1 reticulon 1
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
TCF4 transcription factor 4
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
ATF1 activating transcription factor 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
C6ORF62 chromosome 6 open reading frame 62
CD47 CD47 molecule
CDK4 cyclin-dependent kinase 4
CHPT1 choline phosphotransferase 1
CLU clusterin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYNLT3 dynein, light chain, Tctex-type 3
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAA glucosidase, alpha; acid
HDGFRP3 hepatoma-derived growth factor, related protein 3
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
KIAA0125 KIAA0125
LYPLA1 lysophospholipase I
MATN2 matrilin 2
MBP myelin basic protein
MLF1 myeloid leukemia factor 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
NCK2 NCK adaptor protein 2
NEBL nebulette
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OXTR oxytocin receptor
PBK PDZ binding kinase
PIP prolactin-induced protein
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
REEP5 receptor accessory protein 5
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UGCG UDP-glucose ceramide glucosyltransferase
XPO7 exportin 7
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38