BRD-K84987553_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K84987553_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADCY7 adenylate cyclase 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BLVRB biliverdin reductase B
C6ORF62 chromosome 6 open reading frame 62
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS2 insulin receptor substrate 2
LIMCH1 LIM and calponin homology domains 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
P3H2 prolyl 3-hydroxylase 2
PDLIM4 PDZ and LIM domain 4
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PRAME preferentially expressed antigen in melanoma
S100A2 S100 calcium binding protein A2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ARG1 arginase 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BTG2 BTG family, member 2
CCNG1 cyclin G1
CD24 CD24 molecule
CHGB chromogranin B
CPE carboxypeptidase E
EFHD1 EF-hand domain family, member D1
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
RAD51C RAD51 paralog C
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
ZNF423 zinc finger protein 423