BRD-K84937637_A-275_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-K84937637_A-275_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AHR aryl hydrocarbon receptor
ALB albumin
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZIN1 antizyme inhibitor 1
BEX1 brain expressed, X-linked 1
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FN1 fibronectin 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GREM1 gremlin 1, DAN family BMP antagonist
GYPC glycophorin C (Gerbich blood group)
HOXA5 homeobox A5
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
IRF6 interferon regulatory factor 6
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KIAA1033 KIAA1033
KLHDC10 kelch domain containing 10
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MYO6 myosin VI
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SKAP2 src kinase associated phosphoprotein 2
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX thymocyte selection-associated high mobility group box
TRPS1 trichorhinophalangeal syndrome I
TUBB2A tubulin, beta 2A class IIa
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WEE1 WEE1 G2 checkpoint kinase
WIPF1 WAS/WASL interacting protein family, member 1
WLS wntless Wnt ligand secretion mediator
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AHCY adenosylhomocysteinase
AHNAK2 AHNAK nucleoprotein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMD1 adenosylmethionine decarboxylase 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCDC92 coiled-coil domain containing 92
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CD81 CD81 molecule
CDC25B cell division cycle 25B
CENPA centromere protein A
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
COX5A cytochrome c oxidase subunit Va
COX7B cytochrome c oxidase subunit VIIb
CSK c-src tyrosine kinase
CST3 cystatin C
CTSL cathepsin L
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDRGK1 DDRGK domain containing 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKC1 dyskeratosis congenita 1, dyskerin
DLD dihydrolipoamide dehydrogenase
EBNA1BP2 EBNA1 binding protein 2
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM35A family with sequence similarity 35, member A
FASN fatty acid synthase
FASTKD5 FAST kinase domains 5
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HN1L hematological and neurological expressed 1-like
HOXA10 homeobox A10
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB1BP1 integrin beta 1 binding protein 1
ITGB5 integrin, beta 5
JTB jumping translocation breakpoint
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIG1 ligase I, DNA, ATP-dependent
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MCM2 minichromosome maintenance complex component 2
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NRN1 neuritin 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP62 nucleoporin 62kDa
ODC1 ornithine decarboxylase 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDIA6 protein disulfide isomerase family A, member 6
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
PPA2 pyrophosphatase (inorganic) 2
PRDX4 peroxiredoxin 4
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPN2 ribophorin II
RPS27L ribosomal protein S27-like
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SFPQ splicing factor proline/glutamine-rich
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SSR4 signal sequence receptor, delta
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
STOML2 stomatin (EPB72)-like 2
SYNGR2 synaptogyrin 2
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TECR trans-2,3-enoyl-CoA reductase
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMCO1 transmembrane and coiled-coil domains 1
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM251 transmembrane protein 251
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TRIM28 tripartite motif containing 28
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
URI1 URI1, prefoldin-like chaperone
VCP valosin containing protein