BRD-K84895041_BMY 45778_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K84895041_BMY 45778_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BCAP31 B-cell receptor-associated protein 31
BLVRB biliverdin reductase B
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLDN3 claudin 3
CLU clusterin
COCH cochlin
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSD cathepsin D
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNM1 dynamin 1
DUSP4 dual specificity phosphatase 4
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCGBP Fc fragment of IgG binding protein
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IGF2R insulin-like growth factor 2 receptor
IGFBP6 insulin-like growth factor binding protein 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
MALL mal, T-cell differentiation protein-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEFL neurofilament, light polypeptide
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRN1 neuritin 1
NTS neurotensin
PGRMC1 progesterone receptor membrane component 1
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PNMAL1 paraneoplastic Ma antigen family-like 1
REG1A regenerating islet-derived 1 alpha
RNF13 ring finger protein 13
RTN1 reticulon 1
SCPEP1 serine carboxypeptidase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCEAL2 transcription elongation factor A (SII)-like 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TPD52L1 tumor protein D52-like 1
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WFS1 Wolfram syndrome 1 (wolframin)
WT1 Wilms tumor 1

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
BHLHE40 basic helix-loop-helix family, member e40
CCL2 chemokine (C-C motif) ligand 2
CELF2 CUGBP, Elav-like family member 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DICER1 dicer 1, ribonuclease type III
DLC1 DLC1 Rho GTPase activating protein
EDN1 endothelin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FZD6 frizzled class receptor 6
GATA6 GATA binding protein 6
GTPBP8 GTP-binding protein 8 (putative)
HIST1H2BK histone cluster 1, H2bk
HOOK2 hook microtubule-tethering protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
LDLR low density lipoprotein receptor
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYLK myosin light chain kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PRDX4 peroxiredoxin 4
PTER phosphotriesterase related
RCAN1 regulator of calcineurin 1
RPS11 ribosomal protein S11
SDC2 syndecan 2
SEPT8 septin 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHROOM2 shroom family member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD7 SMAD family member 7
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYND11 zinc finger, MYND-type containing 11